Thursday, January 31, 2013

Steve Fairchild, ex-CSU Rams coach, hired as Virginia coordinator

Steve Fairchild. (The Denver Post)

CHARLOTTESVILLE, Va.???Virginia has hired former Colorado State coach Steve Fairchild to be its offensive coordinator.

Fairchild replaces Bill Lazor, who resigned earlier this week to take a job on Chip Kelly's staff with the Philadelphia. Eagles.

Fairchild, a Colorado State graduate, coached the Rams from 2008-2011. He was 16-33 in his first stint as a head coach after a long career as an assistant.

Before that he had spent two seasons as offensive coordinator with the Buffalo Bills. After being fired by CSU, he returned to the NFL last year to work as an offensive assistant with the San Diego Chargers.

Source: http://feedproxy.google.com/~r/dp-sports/~3/FRQuakspaeE/steve-fairchild-ex-csu-rams-coach-hired-virginia

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New semiconductor research may extend integrated circuit battery life tenfold

New semiconductor research may extend integrated circuit battery life tenfold [ Back to EurekAlert! ] Public release date: 30-Jan-2013
[ | E-mail | Share Share ]

Contact: Michelle Cometa
macuns@rit.edu
585-475-4954
Rochester Institute of Technology

Early results using novel materials and processes achieves milestone toward low-power tunnel transistor electronics

Researchers at Rochester Institute of Technology, international semiconductor consortium SEMATECH and Texas State University have demonstrated that use of new methods and materials for building integrated circuits can reduce powerextending battery life to 10 times longer for mobile applications compared to conventional transistors.

The key to the breakthrough is a tunneling field effect transistor. Transistors are switches that control the movement of electrons through material to conduct the electrical currents needed to run circuits. Unlike standard transistors, which are like driving a car over a hill, the tunneling field effect transistor is more like tunneling through a hill, says Sean Rommel, associate professor of electrical and microelectronic engineering.

"The tunneling field effect transistors have not yet demonstrated a sufficiently large drive current to make it a practical replacement for current transistor technology," Rommel says, "but this work conclusively established the largest tunneling current ever experimentally demonstrated, answering a key question about the viability of tunneling field effect transistor technology."

Rommel worked with David Pawlik, Brian Romanczyk and Paul Thomas, three graduate students in the microelectronic engineering and microsystems engineering programs at RIT. Along with colleagues from SEMATECH and Texas State University, the team presented the breakthrough findings at the International Electron Devices Meeting in San Francisco this past December.

In order to accurately observe and quantify these current levels, a fabrication and testing procedure was performed at RIT. Pawlik developed a process to build and test vertical Esaki tunnel diodes smaller than 120 nanometers in diameter, Rommel explains. This procedure allowed the researchers to measure hundreds of diodes per sample. Because of the nanometer-scale devices tested, the researchers were able to experimentally observe currents substantially larger than any previously reported tunneling currents.

Esaki tunnel diodes, discovered in 1957 and the first quantum devices, were used to create a map showing output tunnel currents for a given set of material systems and parameters. For the first time, researchers have a single reference to which they can compare results from the micro- to the mega-ampere range, Rommel adds.

"This work may be used by others in designing higher performance tunneling field effect transistors which may enable future low power integrated circuits for your mobile device," he says.

The team's findings in the area of developing high performance, low-power electronic devices are also detailed in the paper, "Benchmarking and Improving III-V Esaki Diode Performance with a Record 2.2 MA cm2 Current Density to Enhance Tunneling Field-Effect Transistor Drive Current." The National Science Foundation, SEMATECH and RIT's Office of the Vice President of Research sponsor the work.

"SEMATECH, RIT and Texas State have made a significant breakthrough in the basic materials for the sub 10 nm node with this work," said Paul Kirsch, director of SEMATECH's Front End Processes. "The research that was presented at the International Electron Devices Meeting on III-V Esaki tunnel diode performance resolves fundamental questions on the viability of tunneling field effect transistors and provides a practical basis for low-voltage transistor technologies."

###


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?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


New semiconductor research may extend integrated circuit battery life tenfold [ Back to EurekAlert! ] Public release date: 30-Jan-2013
[ | E-mail | Share Share ]

Contact: Michelle Cometa
macuns@rit.edu
585-475-4954
Rochester Institute of Technology

Early results using novel materials and processes achieves milestone toward low-power tunnel transistor electronics

Researchers at Rochester Institute of Technology, international semiconductor consortium SEMATECH and Texas State University have demonstrated that use of new methods and materials for building integrated circuits can reduce powerextending battery life to 10 times longer for mobile applications compared to conventional transistors.

The key to the breakthrough is a tunneling field effect transistor. Transistors are switches that control the movement of electrons through material to conduct the electrical currents needed to run circuits. Unlike standard transistors, which are like driving a car over a hill, the tunneling field effect transistor is more like tunneling through a hill, says Sean Rommel, associate professor of electrical and microelectronic engineering.

"The tunneling field effect transistors have not yet demonstrated a sufficiently large drive current to make it a practical replacement for current transistor technology," Rommel says, "but this work conclusively established the largest tunneling current ever experimentally demonstrated, answering a key question about the viability of tunneling field effect transistor technology."

Rommel worked with David Pawlik, Brian Romanczyk and Paul Thomas, three graduate students in the microelectronic engineering and microsystems engineering programs at RIT. Along with colleagues from SEMATECH and Texas State University, the team presented the breakthrough findings at the International Electron Devices Meeting in San Francisco this past December.

In order to accurately observe and quantify these current levels, a fabrication and testing procedure was performed at RIT. Pawlik developed a process to build and test vertical Esaki tunnel diodes smaller than 120 nanometers in diameter, Rommel explains. This procedure allowed the researchers to measure hundreds of diodes per sample. Because of the nanometer-scale devices tested, the researchers were able to experimentally observe currents substantially larger than any previously reported tunneling currents.

Esaki tunnel diodes, discovered in 1957 and the first quantum devices, were used to create a map showing output tunnel currents for a given set of material systems and parameters. For the first time, researchers have a single reference to which they can compare results from the micro- to the mega-ampere range, Rommel adds.

"This work may be used by others in designing higher performance tunneling field effect transistors which may enable future low power integrated circuits for your mobile device," he says.

The team's findings in the area of developing high performance, low-power electronic devices are also detailed in the paper, "Benchmarking and Improving III-V Esaki Diode Performance with a Record 2.2 MA cm2 Current Density to Enhance Tunneling Field-Effect Transistor Drive Current." The National Science Foundation, SEMATECH and RIT's Office of the Vice President of Research sponsor the work.

"SEMATECH, RIT and Texas State have made a significant breakthrough in the basic materials for the sub 10 nm node with this work," said Paul Kirsch, director of SEMATECH's Front End Processes. "The research that was presented at the International Electron Devices Meeting on III-V Esaki tunnel diode performance resolves fundamental questions on the viability of tunneling field effect transistors and provides a practical basis for low-voltage transistor technologies."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-01/riot-nsr013013.php

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Wargaming Sets Its Sights On Console Game Development - News ...

Free-to-play MMO developer and publisher Wargaming (World of Tanks) announced its purchase of Day 1 Studios today, which will focus on the development of an unannounced console title. Wargaming intends to have Day 1 focus on console-focused gaming and multi-platform game development.

?The move into console game development is a huge step for Wargaming, as we begin to expand our presence into new platforms," says Victor Kislyi, CEO of Wargaming. "We are looking forward to sharing the fruits of our labor soon."

Currently boasting 45 million players worldwide, Wargaming has directed its attention to its war series dedicated to mid-20th century warfare, two of which having release dates later this year. Recently, Wargaming announced its development of the Wargaming.net service. Wargaming is taking multiple steps to further its multiplatform development.

?Wargaming is a clear leader in the free-to-play space and helps set the standard on which all other games in the genre strive for," says Denny Thorley, new Head of Wargaming's Chicago-based studio. "Our team is extremely excited to start the first console project for Wargaming."

Source: http://www.gameinformer.com/b/news/archive/2013/01/29/wargaming-sets-its-sights-on-console-game-development.aspx

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Apple Accessories: Designing for the iPad

Wed, Jan 30 2013

Never has a device exploded onto the market quite like the digital tablet. While the iPhone has had 7 years to expand its market presence, the iPad has captured a third of Apple?s net sales in less than 3, reshaping the spectrum of everyday electronics. The sudden glut caused the accessory market to explode as a result, producing a wide variety of ?gadgets that range from?genius to?comical. With such an assortment of accessories on the market, it can be hard for new inventors to innovate in this space, especially without stepping into the realm of the superfluous. So how is an Apple enthusiast to make a splash in such a large pool? Simply put, by taking a step back to examine the facts. To offer a little framework, here is a breakdown of the iPad tablets in Apple?s current lineup, along with an overview of their accessory markets.

iPad 2, iPad 3, and iPad with Retina Display

While the iPad with Retina Display may be the latest tablet in Apple?s repertoire, both the iPad 2 and the iPad 3 have a strong enough presence to merit a spot in the ?conversation. Since the basic form factor of these tablets hasn?t changed since 2010, their joint accessory market has had a while to mature, so the wisest approach for a prospective inventor is to reject the status quo. Protective cases, docks, kickstands and reading stands have been sold and refined for years now, so your best bet at finding innovation is to ignore the product?s core use cases entirely: web-browsing in bed, typing, readin on the train, etc. This isn?t to say that new products can?t emerge in this space, but your concept will be competing with a host of major product companies, who have had years to develop their product lines. That?s quite a tall order.

Instead, try to focus your attention on more specific applications, which may not have been touched by mass market brands. Your own areas of expertise are a great place to start: if you love to cook, examine uses for the iPad while you?re in the kitchen; if you?re a frequent flyer, consider how you could improve it for travel. Assess the ideal uses and features of a tablet in that setting (splashproof in the kitchen, shatterproof while hiking, etc.), then examine the current accessory market to see what?s out there, and identify those problems that have still not been addressed. Quirky?s Roadshow and Prep Step (above)?are two products that do this quite well, despite being relatively low tech. Each combines a clever set of features to optimize the iPad for a certain setting, resulting in a unique product with an innovative function. You can?t define ?invention? much better than that.

iPad Mini


In contrast to the flagship line of iPads, the iPad Mini is relatively new to the scene, having been released in late 2012. As a result, its accessory market is somewhat less developed, with more room for products that target a mass market audience. You can read this past article for a more in-depth look at designing for the Mini, but the most important thing to remember is to target the form factor. Don?t think of the Mini as a counterpart to the Kindle Fire or Nexus, because you?re in Apple?s marketplace now. Instead, think of it as a smaller, thinner, lighter iPad, and play to these advantages. Obviously, its reduced size makes it easier to transport and hold, but it also makes it easier for the Mini to interface with other objects, and serve roles that were once exclusive to smart phones. For example, mounting an original iPad on a dashboard would be nigh on ludicrous, but a Mini?s smaller size makes it far less intrusive. To sum things up? Don?t constrain yourself by thinking of this as an iPad. Consider it an entirely new device, and clever new applications will start popping up like daisies.

More In This Series:
Apple Accessories: Designing for the Mac
Monday Design Tip: If You?re Designing For Apple, Design Like Apple

Source: http://aquirkyblog.com/2013/01/apple-accessories-designing-for-the-ipad/

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Power secrets of frequent travelers ? Business Management Daily ...

When the electricity goes out or gets scarce, frequent business travelers like your boss know all the top tricks to power up, discovered freelance journalist Jane L. Levere.

Sales and marketing executive Mark Pearlstein never leaves for a trip without his 92-hour rechargeable backup battery from Brookstone, which he uses to refuel his laptop and smartphone on the go. It helps get business done on the road, but he found it most useful at home during Hurricane Sandy.

Pearlstein used the battery to power his smartphone, which he turned into a mobile hotspot, which delivered Internet to his laptop.

Most travelers have a knack for making do with the resources at hand, says Ron diLeo, executive di??rec??tor of the Association of Cor??por??ate Travel Executives.

?When you?re a frequent traveler, you learn how to charge your phone off your laptop until you can get to a place where you can charge the laptop,? he said.

Many frequent travelers also take advantage of the following gadgets:

  • Backup power for smartphones. These small devices will add hours of charge to a smartphone and are made by several companies, including Duracell and Energizer.
  • Mophie Juice Pack Air. An iPhone case that contains a rechargeable battery that adds up to nine hours of use.
  • Eneloop mobile boosters by Panasonic. These lithiumion back??up batteries can charge a smartphone and a tablet simultaneously.
  • Trent iMirror. A heavy-duty ex??ter??nal battery pack that can also charge a smartphone and a tablet simultaneously.
  • Duracell?s Powermat system. The mat can work while plugged in or charged and transfers power wirelessly to devices you place on it.
  • The HyperJuice system. An ex??ternal battery for Apple products can extend a MacBook?s up to 45 hours and an iPad?s up to 53 hours. It can also recharge an iPhone as many as 52 times.

? Adapted from ?Power Is Where You Find It,? Jane L. Levere, The New York Times.

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Source: http://www.businessmanagementdaily.com/34232/power-secrets-of-frequent-travelers

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Wednesday, January 30, 2013

Israelis offer a 'Yom Huledet Sameach' to Ben Yehuda, resurrector of Hebrew language

Eliezer Ben Yehuda, who transformed Hebrew from the rusty language of ancient Israel and the Bible into the dynamic, dominant language of modern-day Israel, would be 155 years old today.

By Christa Case Bryant,?Staff Writer / January 8, 2013

This December, 2012 photo shows visitors at the Mahane Yehuda market, one of Jerusalem's free tourist attractions. Beyond its earthly past, Jerusalem has an impossible beauty with broad appeal. For residents and tourists, secular and religious souls, city slickers or nature lovers, there is always an unexplored alleyway, street corner or vista that will show you the city as you?ve never seen it before.

Ariel Schalit/AP

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If it weren?t for Eliezer Ben Yehuda, I wouldn?t be able to order ice cream, ask directions to the local furniture store, or discuss Gaza bombings in Hebrew.

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Since I?m a new journalist in Israel who happens to love ice cream and arrived here with only one piece of furniture to my name, that would be grave indeed.

So I for one am grateful for Mr. Ben Yehuda, who was born 155 years ago today in the Russian empire.

Legend has it that the man was not only brilliant, but a little crazy. And you would have to be, if you were planning to try to resurrect an ancient language after roughly 2,000 years and expect it to become the primary spoken language of a country that didn't even exist yet.

But the Sorbonne-educated Ben Yehuda did just that ??well before the state of Israel was founded in 1948, and even before Lord Balfour of Britain made his famous promise to the Zionists in 1917 to help establish a Jewish homeland.

Of course, Hebrew was the language of the Torah ? the biblical books of Genesis, Exodus, Leviticus, Numbers, and Deuteronomy ? as well as other religious writings. So many Jews were familiar with it. But they didn?t use it to talk about things like grocery shopping or even politics.

Where to start? With your family, of course. When Ben Yehuda arrived in Israel with his family, he banned his wife and children from speaking any other language. According to tradition, his family was the first to speak exclusively Hebrew in the home.

He also helped start schools and Hebrew-language newspapers, and published the first dictionary of modern Hebrew, often drawing on biblical words to coin modern terms. Ultra-Orthodox Jews pushed back hard, arguing that Hebrew is a holy language and not to be used to discuss the mundane. Many of them still prefer to speak in Yiddish when discussing daily affairs.

But Hebrew is nevertheless the dominant language in Israel today, although Arabic is an official language as well.

But I digress.

You were wondering about how to order ice cream, right?

G'lida. That?s your ticket.

Todah (thank you), Ben Yehuda.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/8b6aRSWoayI/Israelis-offer-a-Yom-Huledet-Sameach-to-Ben-Yehuda-resurrector-of-Hebrew-language

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Tuesday, January 29, 2013

Russia tries whistleblower, despite his death

FILE - This Monday, Nov. 30, 2009 file photo shows a portrait of lawyer Sergei Magnitsky who died in jail, which is held by his mother Nataliya Magnitskaya, unseen, as she speaks during an interview with The Associated Press in Moscow. Russia is preparing to put lawyer Sergei Magnitsky on trial, even though he is dead, in the latest twist in a case that has severely strained U.S.- Russian relations. Magnitsky, a lawyer for the Hermitage Capital fund, died in jail in 2009 after accusing Russian officials of colluding in stealing $230 million from the state. He was arrested on suspicion of tax evasion by the same Interior Ministry officials he accused. A Moscow court on Monday Jan. 28, 2012 set preliminary hearings in the posthumous trial for Feb. 18. (AP Photo/Alexander Zemlianichenko, File)

FILE - This Monday, Nov. 30, 2009 file photo shows a portrait of lawyer Sergei Magnitsky who died in jail, which is held by his mother Nataliya Magnitskaya, unseen, as she speaks during an interview with The Associated Press in Moscow. Russia is preparing to put lawyer Sergei Magnitsky on trial, even though he is dead, in the latest twist in a case that has severely strained U.S.- Russian relations. Magnitsky, a lawyer for the Hermitage Capital fund, died in jail in 2009 after accusing Russian officials of colluding in stealing $230 million from the state. He was arrested on suspicion of tax evasion by the same Interior Ministry officials he accused. A Moscow court on Monday Jan. 28, 2012 set preliminary hearings in the posthumous trial for Feb. 18. (AP Photo/Alexander Zemlianichenko, File)

FILE - This Friday, Nov. 16, 2012 file photo shows a tombstone on the grave of lawyer Sergei Magnitsky who died in jail, at a cemetery in Moscow. Russia is preparing to put lawyer Sergei Magnitsky on trial, even though he is dead, in the latest twist in a case that has severely strained U.S.- Russian relations. Magnitsky, a lawyer for the Hermitage Capital fund, died in jail in 2009 after accusing Russian officials of colluding in stealing $230 million from the state. He was arrested on suspicion of tax evasion by the same Interior Ministry officials he accused. A Moscow court on Monday Jan. 28, 2012 set preliminary hearings in the posthumous trial for Feb. 18. (AP Photo/Misha Japaridze, file)

(AP) ? Russia is preparing to put lawyer Sergei Magnitsky on trial, even though he died in 2009, an unusual twist in a case that has become a byword for Russian corruption and severely strained U.S. relations with Moscow.

Russia's top court ruled in August 2011 that posthumous trials are allowed, with the intention of letting relatives clear their loved ones' names. In Magnitsky's case, family members say they don't want another trial, yet prosecutors re-filed charges anyway.

The move has outraged human rights groups who see the whistleblower's situation as indicative of the rampant judicial abuse, skyrocketing graft, and blurred boundaries between the state and organized crime that have plagued Russia under President Vladimir Putin.

"The trial of a deceased person and the forcible involvement of his relatives is a dangerous precedent that would open a whole new chapter in Russia's worsening human rights record," Amnesty International said in a recent statement.

Magnitsky drew controversy in 2008 after claiming that an organized crime group colluded with corrupt Interior Ministry officials to claim a $230 million tax rebate through illegally obtained subsidiaries of Hermitage Capital Management, the company of Magnitsky's then-client, London-based investor William Browder.

Those same officials had him arrested and placed in pre-trial detention. Magnitsky and Browder were accused of evading $16.8 million in taxes.

A year later, the 37-year-old Magnitsky died in jail of pancreatitis, after what supporters claim was systematic torture. Russia's presidential human rights council found in July 2011 that Magnitsky had been repeatedly beaten and deliberately denied medical treatment.

A Moscow court on Monday set preliminary hearings in the case for Feb. 18. Magnitsky's mother, Nataliya Magnitskaya, said she had no faith the officials who she believes are complicit in her son's death could give him a fair trial.

"What are they going to say? 'We're guilty and we should be punished?' It's obvious what's going to happen," she said. "They just want a conviction. Maybe they'll change the venue to the cemetery and try Sergei there."

The Russian court ruling allowing posthumous trials came after an appeal by the family of an obstetrician who was killed in a collision with a car of a top oil company executive. Prosecutors reopened Magnitsky's case just days after the 2011 ruling. His mother has since filed 25 appeals asking for the case to be closed.

Browder is being tried in absentia; he has not been to Russia since he was banned from entering the country in 2005.

"To try a dead man is beyond evil," Browder told The Associated Press in a telephone interview Monday. "This is a politically directed prosecution ? Putin and (Prime Minister Dmitry) Medvedev have both directed, have sent the instructions for the outcome of this case."

Russia's troubled criminal justice system has a long history of staging grandiose, politically motivated trials aimed at sending a message to opponents of the state. Under Joseph Stalin, the Soviet Union saw numerous show trials of top officials, many of which ended with summary executions.

In modern Russia, vaguely defined charges of "economic crimes" are frequently used to seize assets and silence political opponents such as former oil tycoon Mikhail Khodorkovsky. One in six Russian businessmen have been accused of "economic crimes" since 2002, according to the country's business ombudsman.

Browder has used a website, Russian Untouchables, to post material that allegedly shows the officials accused by Magnitsky became substantially wealthier after the tax rebate, spending vastly in excess of their meager official salaries on international travel, luxury cars, and prime real estate in Dubai. The Russian officials deny any wrongdoing.

Officials in Switzerland, Cyprus, Latvia, Lithuania, and Estonia are attempting to trace portions of the $230 million rebate to banks in those countries.

Putting Magnitsky on trial posthumously underscores the Kremlin's defiance amid growing international concern over Russia's human rights record and corruption.

Last December, tensions between the U.S. and Russia flared when Congress passed a law named after Magnitsky sanctioning officials Browder accuses of involvement in the fraud. Browder says he hopes the European Union will pass its own Magnitsky act by the end of the year.

Russia responded to the U.S. law by banning adoptions of Russian children by Americans and dropping charges against a prison doctor on trial for negligence in Magnitsky's death.

Putin at that time said that Magnitsky died of a heart attack and accused Browder of politicizing his death to distract from his own crimes. The Russian president has decried the Magnitsky law as an "anti-Russian" attempt by Congress to impose America's will on Russia's sovereignty.

"Why does one country think it has the right to spread its jurisdiction all over the world?" he asked during a news conference in December.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-01-28-EU-Russia-Magnitsky-Trial/id-95ec4891edec4f22aad5b9eb9a79c7d1

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Small town social media ? Local News ?

Many people probably don?t remember the last billboard they saw.

Some people probably don?t remember the last Facebook status they read.

That?s why T.J. Kaikobad says there?s little difference between I-75 and the information highway. When it comes to advertisements ? whether it?s a billboard or a Facebook timeline post ? attention spans don?t last long.

?But for any small town business, social media is like raw electricity,? Kaikobad said. ?That?s why it?s so important to grab a customer?s interest right away. You?ve just got to flip the switch to turn the lights on. But like any other tool, it?s only as good as you use it. The more you know about it, the better. In the early days, people thought, ?I?ll just go and put this out on Facebook. It will make me untold riches.? If it was that simple, there would be a lot of people with untold riches.?

Maybe it?s not getting him untold riches, but Kaikobad, owner of the Dalton Depot restaurant, is one of several local business owners who rely on social media like Facebook to build their business. James Kelley, director of digital strategy at h2b creative, a Dalton advertising firm, says using social media has given an edge to several business owners here.

?I?ve been in Dalton for four years and I?ve seen the dramatic change for business,? Kelley said. ?Social media is helping business owners influence northwest Georgia and I think we?re better than some others in the country. What local businesses are doing is what we call ?so-lo-mob,? or social local mobile. It?s interacting and creating an online community that is built exclusively in Dalton. It helps businesses here compete in the larger social media community, letting them fight the curve with Chattanooga and Atlanta.?

One tool in that fight is Foursquare, a social networking application that lets smartphone users log their visits to nearby locations using their phone?s global positioning system (GPS). Rusty Davis, owner of Iron Gate Pizzeria, uses Foursquare to get demographic information from his customers. Anyone who checks into the restaurant gets a 10 percent discount.

?That encourages them to log in and that provides me with so much information (from the person?s profile), which is surprising for an app that?s free of charge,? Davis said. ?Foursquare really has that pyramid effect where if one person checks in, everyone they know sees it. Then maybe one or two more people build on that and check in. And then more see it ... It?s really more about building loyalty as opposed to getting new business, but there?s no charge so it?s great.?

The cost-free aspect of social media is what makes it so appealing, Kaikobad said.

?Too often, trial and error in advertising comes at a cost,? he said. ?Social media kind of removes that cost and lets you experiment to see what works and what doesn?t work. Sometimes, with other types of advertising, when you go through trial and error and by the time you go through the learning curve, you?ve had a huge loss somewhere.?

Larger companies might still have losses.

?Big companies have spent millions of dollars on research to figure out how to offer good customer service through social media,? Kelley said. ?But the businesses in Dalton have been able to use social media on a smaller level and still provide relationships and service that big businesses cannot give.?

All of the benefits of social media don?t make it ?a magic wand,? Kaikobad said.

?Maybe it was for (Mark) Zuckerberg and the gang,? he added. ?But for me, I see it as another tool you have to learn. Getting out there on Facebook and making a post doesn?t cut it. You have to know what you?re doing.?

Kelley agrees.

?There?s no insta-magic formula here,? he said. ?Social media is about relationships, and building relationships ? online or off ? takes time and dedication. Businesses should already know this, since they?ve been built on relationships since the beginning of time.?

The benefit of social media is that business owners can create online ?ambassadors? who can carry their products throughout the Internet.

?It?s about building loyalty,? Kelley said. ?You could have a million followers and not provide a quality service. It?s not going to do what one real relationship could do for you. But if you have, say, 250 likes on your Facebook page and you?re very engaged with them ? well then you have loyalty that can spread over to a million people.?

Kasey Carpenter, owner of the Oakwood Cafe and the Sweet Spot, says he builds most of his loyalty at the Sweet Spot with a text service that offers discounts to return customers. Customers give their cellphone number to the person at the register and with each sixth purchase of frozen yogurt get a discount off their seventh purchase.

?We have about 12,000 members with that loyalty program,? Carpenter said. ?That?s a pretty good program. We?re more than pleased with it. Advertising has been increasingly difficult and I don?t see businesses growing if they don?t use social media.?

The texting service is good for return customers, Carpenter said, but when it comes to bringing in new business he turns to Facebook.

?The Sweet Spot?s Facebook page has about 6,000 likes right now and the Oakwood has about 4,000 likes,? he said. ?I?d say that social media is responsible for about 40 percent new business. People share things on their walls if we have a special. It?s especially good for grand openings. But with social media, you have to keep it fresh. You have to constantly update to keep customers interested. It?s a necessary evil. That?s how the world works now and if you don?t do it then you?re missing the boat.?

Even if a business owner is on the boat they have to be relevant in their social media activity if they?re expecting to build relationships, said Katie Freeland, a copywriter and social media strategist with h2b.

?Being successful with social media has to do with monitoring what people are actually talking about,? Freeland said. ?You have to watch viral videos and read news articles that people share a lot. You have to go off that as a foundation to create a conversation that?s engaging. You have to relate with customers instead of having a static headline that doesn?t ask for any interaction. You don?t want to throw a product out on a social media platform and just walk away from the process.?

But you don?t want to rely too much on social media either, Freeland added.

?I think it?s a good first step and it starts moving things in the right direction, but you want to take the next step to move the relationship offline to make it a more personal relationship. That?s what builds the bigger networks, bigger customer bases.?

Building a customer base is what Danielle Kaikobad, T.J. Kaikobad?s wife and owner of the Coffee Train, is trying to do.

?We?re in our first year ? we opened in October ? so we?re using social media to get the word out,? she said. ?We also use an app called Square Wallet. It lets you save your bank information on your phone and pay from your phone. You never even have to walk up to the register. You can even prepay before you get there. If you forget your wallet, you can still get your coffee. Every second counts sometimes. Sometimes, people only have a 5-minute break before they have to go back to work. We also have a card slider on an iPad that lets people get in and out quickly, but being able to pay beforehand has really helped business. That said, you can?t just cut out the older generation. You have to meet both. Not everyone checks their iPhone or Facebook for a promotion.?

No matter which generation is involved, business owners must stick with ?the basics of marketing,? T.J. Kaikobad said.

?The basics are ... you?ve got to capture the person?s attention, deliver your message and seal the deal in 15 seconds or less,? he said. ?In the old days, I was a big paragraph person. I wanted to tell everyone about everything. You can?t do that anymore. Attention spans are down to bullet points now.

?If you get out there and do a huge paragraph on these great oysters you have, talking about how these oysters are limited and well-maintained, maybe 200 people see it. But maybe only one will read the whole paragraph. And maybe he?ll be like, ?Man, this is pretty cool. Oh well. I don?t like oysters.??

If big paragraph posts don?t work for business owners, what does?

?Genuine enthusiasm,? Kaikobad said. ?Out biggest Facebook promotion was last year for ?80s Night. We?re having it again this year (it was Saturday), but people seem a bit complacent about it. I remember... when we started promoting it back in 2012 there was so much excitement. That excitement came through when we would put it out there on Facebook and people responded, they got excited, too, and it turned out great. There?s no substitute or formula that can recreate enthusiasm and drive.?

That might be why social media works, Carpenter said.

?It keeps you on your game,? he said. ?Thirty years ago, you would take a yellow page out in the Yellow Book. Or maybe you would do a radio ad and leave it alone. Maybe business owners got a little lazy with advertising. Now you have to constantly be creative and competitive. It keeps you from sitting on your hands because you?re reinventing the wheel every three or four weeks. It?s challenging sometimes, but that?s good.?

Kelley agrees.

?At the end of the day, there is no set strategy for every business,? he said. ?Like any aspect of a good business, social media is about building engaging content and giving the client what they want. That?s what people should keep in mind.?

Source: http://daltondailycitizen.com/local/x503834475/Small-town-social-media

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Accelerating neutral atoms on a table top

Jan. 27, 2013 ? Charged particle accelerators have become crucially important to modern day life, be it in health care for cancer treatment or for answering important fundamental scientific questions like the existence of the HIGGS boson, the so called 'God particle'.

In a simple picture, charged particles like electrons and protons are accelerated between two end plates across which an electrical voltage is applied. High energies need high voltages (millions and billions of volts) and long acceleration paths in giant sized machines -- for instance the trillion volt machine called the 'large hadron collider' (LHC) which discovered the Higgs boson, circles over 27 km underground in Geneva! A new concept for a compact accelerator was discovered in the last decade using high powered, short pulses of laser light.

Alternating large electric fields of the light can be transformed in plasmas to create quasi static fields that can produce hundreds of millions volt accelerating voltages just over millimeter lengths on a table top!

How do we accelerate neutral particles -- i.e. particles that cannot be energized by electrical voltages? And do it over millimeters rather than hundreds of meters and moreover using lasers? Research at Ultra Short Pulse High Intensity Lab in TIFR has now found a novel scheme that can do precisely this. The concept uses the ability of powerful lasers to strip nearly 8 electrons per atom in a nano sized, cooled aggregate of argon atoms- a nano piece of ice. A 40,000 atom cluster of argon is charged to 320,000 by a laser that lasts only a 100 billionth of a millionth of a second. Such a super highly charged ice piece explodes soon after, accelerating the charged atoms (Ions) to a million electron volts of energy. The TIFR research now found that all the expelled electrons can be put back into the charged ion that has been accelerated so that it now reverts to being a neutral atom but at high energies. To top it all, this process is nearly 100% efficient at neutralizing the speeding ions and converting them to fast atoms.

Accelerated neutral atoms are very important for many applications. Unaffected by electric or magnetic fields, they penetrate deeper in solids than electrons/ions and thereby create high finesse microstructures for novel electronics and optical devices. Fast atoms are used both as diagnostics and heating sources in Tokomak machines like the ITER (International Thermonuclear Experimental Reactor) in France, that are being developed to create sustained thermo-nuclear fusion. The TIFR scheme can produce a point source of fast neutral atoms close to the location of an intended application.

This certainly shows that staying neutral under extreme provocation has its advantages.

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The above story is reprinted from materials provided by Tata Institute of Fundamental Research, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


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Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/k-thzKvbSYA/130127134204.htm

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Monday, January 28, 2013

Japan to be first with 4K TV broadcast starting in 2014 - AfterDawn

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Source: http://www.afterdawn.com/news/article.cfm/2013/01/27/japan_to_be_first_with_4k_tv_broadcast_starting_in_2014

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Plume for Twitter (for Android)

By Max Eddy

Just because Twitter is working to curtail non-canonical clients doesn't mean that developers have stopped trying to deliver its 140-character utterances in better and better ways. Plume for Twitter brings a highly customizable Twitter client to Android devices (free, $4.99 to remove ads) with a powerful muting feature to help you manage the chaos of Twitter.

Starting up Plume for the first time, users are greeted by a colorful screen and Plume's cute, friendly duck/penguin masot. Once inside the app, Tweets are displayed in a series of scrolling columns, showing @ replies, the latest updates, direct messages, and so on. Users can scroll up and down to move chronologically through the feeds, and left and right between feeds. Swiping left to right from off the screen will open a hidden tray of other features, such as search and trending topics.

The Sound of Silence
By far, Plume's strongest and most useful feature is "muting" certain users, words, and services from appearing in your feed. One of the drawbacks of Twitter, and it is surely like this by design, is that ?the only way to remove a user from your feed is to un-follow them?a public and noticeable act. Twitter's Lists feature helps, but it lacks fine-grain controls. If you mute a user in Plume, you'll still appear as their follower and you can unmute them at any time. For a sticky social situation, or a power user who has accounts he or she is obliged to follow, "muting" is a powerful tool.

Plume also has the ability to mute Tweets that contain certain words or phrases, as defined by the user. For everyday folks, this is a great way to avoid the weekly cavalcade of #FF tweets, Apple product announcements, or particularly tiresome memes from invading your Twittersphere. For people with PTSD or emotional triggers, being able to hide certain terms from view could make participating in Twitter a far less stressful experience.

Users can manage all their mutes from the settings menu, including muted updates from other apps that publish on Twitter.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/N_Kfc4j1Cvs/0,2817,2414773,00.asp

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Sunday, January 27, 2013

UFC on Fox 6 results: Demetrious Johnson retains title, ?Rampage? loses in Octagon finale

CHICAGO -- The UFC's stop in the Windy City had two great knockouts, a champion holding onto his belt, and the last fight of a one-time champ.

Despite a strong start by John Dodson, Demetrious Johnson held onto his championship belt with a unanimous decision. The judges saw it 48-47, 49-46, 48-47 for Johnson.

Unsurprisingly, Johnson and Dodson fought a fast-paced first two rounds. Johnson tried to slow things down in the first round with a takedown. While he did get Dodson to to the ground, the challenger popped back to his feet quickly.

Dodson dropped Johnson twice in the second round, and shook off Johnson's take down attempts with a great sprawl. Johnson seemed to have a hard time even getting close to Dodson to land a punch.

A Johnson knee in the fourth round caused a small fight stoppage. Dodson's hand was on the ground as Johnson threw a knee to Dodson's head, which is an illegal strike. The bout was stopped as doctors checked Dodson's eye and Johnson was warned. The fight went on, but not without plenty of boos from the crowd in Chicago.

When the fight restarted, it was all Johnson. He controlled Dodson against the cage, and threw knees that busted up Dodson's face. Johnson was able to get a takedown at the beginning of the fifth round, too. Though boos rained down, Johnson kept the fight against the cage.

Later, the crowd got behind him as Johnson elevated, tightened his legs around Dodson's torso and threw elbows. It was a creative move that likely could only happen in the flyweight division. Johnson finished the round with Dodson against the cage, and knee after knee after knee to the body and face.

Quinton 'Rampage' Jackson vs. Glover Teixeira

If this really was Quinton "Rampage" Jackson's last fight in the UFC, it wasn't one to remember. He was outstruck and outwrestled by Glover Teixeira throughout their bout. Teixeira took the fight 30-27, 30-27, 29-28 on the judges' cards.

Teixeira's first round was his best, as he was able to take Jackson down early and mount him and take his back. Late in the round, Teixeira knocked Jackson down with a punch and looked close to finishing, but wasn't able to end the fight.

The rest of the fight featured a worn out Jackson trying to avoid Teixeira's takedown attempts unsuccessfully. Jackson threw some big punches, and even jawed at Teixeira during the bout, but he wasn't able to score any big offense.

While this fight will be remembered for being Jackson's last UFC bout, Teixeira scored his third straight UFC win on Saturday night. He looked impressive against the former champ.

Anthony Pettis vs. Donald Cerrone

Anthony Pettis won his much anticipated bout with Donald Cerrone by landing big, memorable strikes. Pettis was getting the better of their striking exchanges early, which set him up for a big finish. Pettis threw a kick that landed hard on Cerrone's body, then finished with a punch. Cerrone fell to the ground in a heap, and the fight was stopped at 2:35 in the first round.

Pettis lost his first fight in the UFC after coming from the WEC as the champ, but he's been winning ever since. He has wins over Joe Lauzon, Jeremy Stephens and now Cerrone. After the fight, he made a pitch to UFC president Dana White.

"I want my title shot. I should have had it years ago. People say I can?t wrestle because of the Guida fight, but I had a serious shoulder injury. Now I am 100 percent. No one can do in the Octagon what I can do."

While lightweight champion Benson Henderson has a fight set up with Gilbert Melendez, a shot for Pettis isn't unwarranted. It would be a rematch of their WEC title fight, which Pettis won in the promotion's final fight.

Ricardo Lamas vs. Erik Koch

Lamas won the first round by constantly pressuring Koch against the cage. It wasn't exactly the most thrilling round to have start a card on network television, but it led to a thrilling second round. Lamas took advantage of Koch's slip, and then finished the fight with nasty, nasty ground and pound. Lamas started with elbows, then started with strikes that cut open Koch's face. Koch had no answer for Lamas' relentless strikes, and the bout was stopped at 2:32 in the second round.

Lamas thought his performance warranted a title shot.

"I?ve beat Cub Swanson, I?ve beat Hioki and now I?ve beat Koch. All those guys were supposed to be fighting for the title at one point. I beat them all. We?re all here to be world champ and I am no different. I want the winner of Aldo vs Edgar next week. I don?t care who wins, I want the winner."

Source: http://sports.yahoo.com/blogs/mma-cagewriter/ufc-fox-6-results-demetrious-johnson-retains-title-032827859--mma.html

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Free income tax advice today | Biz Beat Blog

Got questions about your income taxes? Confused about changes in tax law as a result of the fiscal cliff negotiations? Members of the Dallas CPA Society will answer your tax questions from noon to 4 p.m. today during our annual free Tax Hotline. Call 214-977-2349 with your questions.

This entry was posted in Personal finance, Taxes and tagged Income tax, tax credits, tax deductions, tax refunds by Pamela Yip. Bookmark the permalink.

Source: http://bizbeatblog.dallasnews.com/2013/01/free-income-tax-advice-today.html/

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Mass Human Sacrifice? Pile of Ancient Skulls Found

Archaeologists have unearthed a trove of skulls in Mexico that may have once belonged to human sacrifice victims. The skulls, which date between A.D. 600 and 850, may also shatter existing notions about the ancient culture of the area.

The find, described in the January issue of the journal Latin American Antiquity, was located in an otherwise empty field that once held a vast lake, but was miles from the nearest major city of the day, said study co-author Christopher Morehart, an archaeologist at Georgia State University.

"It's absolutely remarkable to think about this little nothing on the landscape having potentially evidence of the largest mass human sacrifice in ancient Meso-America," Morehart said.

Middle of nowhere

Morehart and his colleagues were using satellite imagery to map ancient canals, irrigation channels and lakes that used to surround the kingdom of Teotihuacan (home to the Pyramid of the Sun), about 30 miles (50 kilometers) from Mexico City. The vast ancient kingdom flourished from around A.D 200 to 650, though who built it remains a mystery. [In Photos: Amazing Ruins of the Ancient World]

In a now drained lake called Lake Xaltocan, around which was essentially rural farmland at the time, Morehart stumbled upon a site with evidence of looting.

When the team investigated, they discovered lines of human skulls with just one or two vertebra attached. To date, more than 150 skulls have been discovered there. The site also contained a shrine with incense burners, water-deity figurines and agricultural pottery, such as corncob depictions, suggesting a ritual purpose tied to local farming. [See images from the grisly excavation ]

Carbon dating suggested that the skulls were at least 1,100 years old, and the few dozen analyzed so far are mostly from men, Morehart told LiveScience. The researchers did not release photos of the skulls because the sacrifice victims may have historic ties to modern-day indigenous cultures.

The findings shake up existing notions of the culture of the day, because the site is not associated with Teotihuacan or other regional powers, said Destiny Crider, an archaeologist at Luther College in Iowa, who was not involved in the study.

Human sacrifice was practiced throughout the region, both at Teotihuacan and in the later Aztec Empire, but most of those rituals happened at great pyramids within cities and were tied to state powers.

By contrast, "this one is a big event in a little place," Crider said.

The shrines and the fact that sacrifice victims were mostly male suggest they were carefully chosen, not simply the result of indiscriminate slaughter of a whole village, Crider told LiveScience.

Many researchers believe that massive drought caused the fall of Teotihuacan and ushered in a period of warfare and political infighting as smaller regional powers sprang up, Morehart said.

Those tumultuous times could have spurred innovative ? and bloody ? practices, Crider said.

"Maybe they needed to intensify their activities because everything was changing," she said. "When things are uncertain you try new strategies."

Follow LiveScience on Twitter @livescience. We're also on Facebook?& Google+.?

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/mass-human-sacrifice-pile-ancient-skulls-found-152724186.html

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Saturday, January 26, 2013

Video: Coincidence in the age of conspiracy

Sorry, Readability was unable to parse this page for content.

Source: http://video.msnbc.msn.com/hardball/50592586/

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Home Staging Tips - Travis Bell and Robbie Henderson

Home Staging and The WOW Factor ?

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Why not combine Spring Cleaning & Home Staging techniques to set your home apart from other homes in the marketplace?

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The true definition of Home Staging: In its simplest form, it is the art of preparing your home to create maximum Buyer appeal.? This includes creating better traffic flow, de-cluttering, de-personalizing, sometimes painting, freshening up linens and bathrooms, and creating ?WOW? spaces. ?When a potential Buyer walks into your home they want to be able to visualize their life in that space. ?With subtle changes, you can create warm, inviting spaces that people can not only relate to, both visually and emotionally, it is an unspoken understanding that this home will be a template that should be inviting enough to encourage someone to recreate a similar space for their own family. ?If your furniture is placed in unusual spaces, is tattered or out of style or if the room is over crowed with ?things? it will tend to distract the Buyer from the real reason that they are there in the first place?and that is to consider buying your home! ?That is what you ultimately want them to notice?your beautiful home!

The Bell Henderson Team is excited to offer this service as a complimentary consultation in conjunction with the process of listing your home & preparing for the introduction to the marketplace.? We are proud to have Karla Dorsey, a Certified Professional Real Estate Stager on our staff. ?Karla will assist you with the basics of preparing your home for photographs and potential Buyers. ?She will help you see your home through the ?Eyes of a Buyer.?

Should you have questions about how we can sell your current home, do not hesitate to contact the Bell Henderson Real Estate team at 813.931.5000 or Priority@BellHenderson.com.

Tags: Exclusive, Home Staging, Luxury, Tell Me Something Good

Source: http://www.bellhenderson.com/2013/01/25/home-staging-tipsits-the-perfect-time-of-year-to-prepare-your-home-for-sale/

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Spartacus War of The Damned episode 1 Following virtually two years of ups, downs and more than the usual tiny bit of drama, could it be one particular huge Spartacus War of The Damned episode 1 blissful family members at Christian Dior now, with Raf Simons sitting for the Spartacus War of The Damned episode 1 head belonging to the table?
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Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/S2wck69QGQk/viewtopic.php

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TaxACT Deluxe Online

By Kathy Yakal

2nd Story Software has had the distinction over the last several years of being the only personal income tax-prep provider that offers a free version that is the same as its paid version in terms of actual tax preparation tools. The free version of TaxACT Deluxe Online only lacks some found extras found in the paid version, such as an import tool, donation tracker, and calculators (none of which I even used in my evaluation). But if you don't need to file a state return, you can prepare and print or e-file your IRS 1040 forms and schedules absolutely free.

It's for this reason that I said last year and will say again this year: The TaxACT site should be your first stop when you're getting ready to endure your annual tax ordeal. Jump to the topics that you think are the most complex in your return and see how the site handles them. If the forms you need are supported?TaxACT includes all of the most common and many that are used less frequently?and the depth of guidance is acceptable, you don't have to look any further.

Lest you think this is a gimmick designed to market a lot of other products and services to you, or that TaxACT is a second-rate site published by a fly-by-night company, know that it's neither. TaxACT has been around for as long as its competitors, though in its earlier years it was known as Personal TaxEdge and published by a different company (some of the principals moved forward with the product and kept it going under a new name). There's no catch. TaxACT Deluxe Online is a solid rival for the other sites reviewed here. It just happens to be free.

Almost a Carbon Copy
Like its competitors, TaxACT looks and works much like the 2011 version did, with one big difference: TaxTutor Guidance, which comes from renowned tax resource J.K. Lasser, has been rewritten to be clearer and simpler. This was one of TaxACT's weaknesses, so the change was welcome. Beyond that, the company is now offering an audit insurance plan ? similar to competitors' ? for $39.95. And 2nd Story Software is branching out a bit; it will produce an inexpensive service for creating your own will.

TaxACT Deluxe Online does practically everything TurboTax Deluxe Online?and H&R Block At Home Deluxe Online?do. Besides supporting a comparable number of forms and schedules and incorporating new tax laws since last year, it walks you through an interview-like process ("Q&A") rather than making you enter data on IRS documents. It asks you simple, clear questions about everything that needs to be on those official forms. There are often several questions on each screen, and you simply enter information in fields or select options from lists or check boxes to answer them.

You advance forward and backward by clicking buttons. TaxACT doesn't force you to complete the screens in order like H&R Block At Home Deluxe Online does. And when you come across particularly complex topics, all of these sites offer the option of taking a more directed, simplified route.

In the background, TaxACT transfers those responses to the correct lines on the 1040 and its assorted forms and schedules. When you're done, TaxACT combs through your return and alerts you to anything that's missing or seems incorrect. After you've fixed anything necessary, what comes out when you click "Print" is the actual IRS forms filled out with the information you provided. You can also file your return electronically at no cost.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/AEsUWegQR40/0,2817,2414608,00.asp

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Friday, January 25, 2013

Researchers discover new mutations driving malignant melanoma

Friday, January 25, 2013

Two new mutations that collectively occur in 71 percent of malignant melanoma tumors have been discovered in what scientists call the "dark matter" of the cancer genome, where cancer-related mutations haven't been previously found.

Reporting their findings in the Jan. 24 issue of Science Express, the researchers from Dana-Farber Cancer Institute and the Broad Institute said the highly "recurrent" mutations ? occurring in the tumors of many people ? may be the most common mutations in melanoma cells found to date.

The researchers said these cancer-associated mutations are the first to be discovered in the vast regions of DNA in cancer cells that do not contain genetic instructions for making proteins. The mutations are located in non-protein-coding DNA that regulates the activity of genes.

This non-coding DNA, much of which was previously dismissed as "junk," accounts for 99 percent of a cell's genome. A large number of oncogenic mutations in cancer have been identified in the past several decades, but all have been found within the actual genetic blueprints for proteins.

"This new finding represents an initial foray into the 'dark matter' of the cancer genome," said Levi Garraway, MD, PhD, of Dana-Farber and the Broad and the article's senior author.

"In addition, this represents the discovery of two of the most prevalent melanoma gene mutations. Considered as a whole, these two TERT promoter mutations are even more common than BRAF mutations in melanoma. Altogether, this discovery could cause us to think more creatively about the possible benefits of targeting TERT in cancer treatment or prevention."

The mutations affect a promoter region ? a stretch of DNA code that regulates the expression of a gene ? adjacent to the TERT gene. TERT contains the recipe for making telomerase reverse transcriptase, an enzyme that can make cells virtually immortal, and is often found overexpressed in cancer cells. A promoter region of DNA controls the rate of a gene's transcription ? the copying of its DNA recipe into a message used by the cell to manufacture a protein.

"We think these mutations in the promoter region are potentially one way the TERT gene can be activated," said Franklin Huang, MD, PhD, co-first author of the report along with Harvard MD-PhD student Eran Hodis, of Dana-Farber and the Broad Institute.

To investigate the mutation's effect, the researchers hooked the mutant TERT promoter to a gene that makes luciferase ? a light-emitting protein. They observed that the mutant promoter increased the production of luciferase in laboratory cell lines. In the same way, the scientists presume, the mutant promoter in human pigmented skin cells can send the TERT gene into overdrive, potentially contributing to the development of melanoma.

The mutations were discovered when the scientists sifted through data from whole-genome sequencing of malignant melanoma tumors. Unlike "whole-exome" searches that examine only the protein-coding DNA of a cell's genome, whole-genome searches scan all of the DNA, including the non-coding regions.

In analyzing whole-genome data, the investigators discovered the two somatic, or not-inherited, mutations in 17 of 19 (89 percent) of the tumors. Next, they sequenced a larger number of melanoma tumors and found that the two mutations were present in 71 percent of tumors in total.

The researchers said the same mutations are present in cell lines from some other malignancies, and that preliminary evidence showed they might be unusually common in bladder and liver cancers. They also noted that the discovery of these important mutations in DNA previously not linked to cancer-causing alterations highlights the value of whole-genome searches of tumor DNA.

###

Dana-Farber Cancer Institute: http://www.dfci.harvard.edu

Thanks to Dana-Farber Cancer Institute for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 13 time(s).

Source: http://www.labspaces.net/126468/Researchers_discover_new_mutations_driving_malignant_melanoma_

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MIDI spans 30 years at NAMM with Commodore 64 and Animoog (video)

MIDI spans 30 years at NAMM with Commodore 64 and Animoog (video)

You may have heard that the Musical Instrument Digital Interface protocol (aka MIDI) celebrates its 30th birthday this year. And where better than NAMM would the MIDI Manufacturer Association be able to fully demonstrate (and celebrate) the persevering protocol's coming of age? Part of the MMA's installation was a set-up destined to get geek hearts racing. A 1983 Commodore 64 connected to a Sequential Circuits Model 64 sequencer cartridge (with MIDI interface). From these vintage parts, the regular 5-pin MIDI cable heads out through the decades and into an IK Multimedia iRig MIDI, into an iPad, finally feeding its information into the Animoog app from equally longevous Moog. Watch old meet new in the gallery and video below.

Billy Steele contributed to this report.

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Source: http://www.engadget.com/2013/01/25/midi-turns-30-commodore-64-animoog/

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